germline

[US]/dʒɜːm.laɪn/
[UK]/dʒɜrm.laɪn/
Frequency: Very High

Translation

n.the lineage of cells that give rise to gametes (sperm or eggs) in an organism, capable of transmitting genetic material to offspring
adj.relating to or occurring in the germline

Example Sentences

germline mutations are hereditary alterations in dna that are passed from parents to their offspring.

doctors often recommend germline testing for patients with a strong family history of certain cancers.

a germline mutation in the brca1 gene significantly increases the risk of developing breast and ovarian cancer.

unlike somatic mutations, germline mutations are present in every cell of the body throughout a person's life.

scientists use advanced gene editing tools like crispr to target specific germline cells in laboratory settings.

germline gene therapy raises complex ethical questions regarding the permanent modification of human heredity.

identifying a germline variant helps clinicians select the most effective targeted therapies for cancer treatment.

the germline undergoes meiosis to produce haploid gametes necessary for sexual reproduction.

genetic counselors explain the implications of germline inheritance to families planning for future children.

distinctions between somatic and germline mutations are fundamental in the study of oncology and genetics.

her germline status was positive for the genetic mutation, prompting her siblings to get tested as well.

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