orthosteric

the orthosteric site of the receptor is crucial for ligand binding.

orthosteric modulators can enhance or inhibit receptor activity.

we investigated the orthosteric binding pocket using computational modeling.

orthosteric agonists activate the receptor in a canonical manner.

the orthosteric ligand occupies the primary binding site.

developing orthosteric drugs can be a challenging process.

orthosteric allosteric modulators are a novel class of compounds.

the orthosteric effect was observed in the presence of the agonist.

site-directed mutagenesis revealed key residues in the orthosteric region.

orthosteric compounds often exhibit high receptor selectivity.

we analyzed the orthosteric binding affinity of several candidate drugs.