ruination

Overwork is the ruination of his health.

commercial malpractice causes the ruination of thousands of people.

The ruination of the environment is a pressing issue that needs to be addressed.

The ruination of the old building was a result of neglect and lack of maintenance.

The ruination of their friendship came as a shock to everyone.

The ruination of the company was caused by poor management decisions.

The ruination of his reputation was swift and irreversible.

The ruination of the crops due to the drought led to food shortages in the region.

The ruination of her dreams crushed her spirit.

The ruination of the painting was a tragedy for art lovers everywhere.

The ruination of the historic monument was met with outrage from the community.

The ruination of their plans left them feeling lost and directionless.