mephenytoin is an anticonvulsant drug used to treat refractory epilepsy.
美芬妥英是一种用于治疗难治性癫痫的抗惊厥药物。
the metabolic pathway of mephenytoin involves specific cytochrome p450 enzymes.
美芬妥英的代谢途径涉及特定的细胞色素p450酶。
researchers use mephenytoin as a probe drug to phenotype cyp2c19 activity.
研究人员使用美芬妥英作为探针药物来表型cyp2c19活性。
dosage adjustments for mephenytoin are often necessary due to genetic polymorphisms.
由于基因多态性，美芬妥英的剂量调整通常是必要的。
adverse effects associated with mephenytoin include drowsiness and skin rash.
与美芬妥英相关的不良反应包括嗜睡和皮疹。
the clinical use of mephenytoin has declined with the introduction of safer alternatives.
随着更安全替代品的引入，美芬妥英的临床使用已经减少。
hydroxylation of mephenytoin is significantly slower in poor metabolizers.
在弱代谢者中，美芬妥英的羟基化速度明显较慢。
physicians monitor blood levels to prevent mephenytoin toxicity during long-term therapy.
医生监测血液水平以防止长期治疗期间出现美芬妥英毒性。
chronic administration of mephenytoin may induce hepatic microsomal enzymes.
长期服用美芬妥英可能会诱导肝微粒体酶。
this study investigates the pharmacokinetics of mephenytoin in human subjects.
本研究调查美芬妥英在人体受试者中的药代动力学。
severe gingival hyperplasia is a potential side effect of taking mephenytoin.
严重的牙龈增生是服用美芬妥英的潜在副作用。
mephenytoin is an anticonvulsant drug used to treat refractory epilepsy.
美芬妥英是一种用于治疗难治性癫痫的抗惊厥药物。
the metabolic pathway of mephenytoin involves specific cytochrome p450 enzymes.
美芬妥英的代谢途径涉及特定的细胞色素p450酶。
researchers use mephenytoin as a probe drug to phenotype cyp2c19 activity.
研究人员使用美芬妥英作为探针药物来表型cyp2c19活性。
dosage adjustments for mephenytoin are often necessary due to genetic polymorphisms.
由于基因多态性，美芬妥英的剂量调整通常是必要的。
adverse effects associated with mephenytoin include drowsiness and skin rash.
与美芬妥英相关的不良反应包括嗜睡和皮疹。
the clinical use of mephenytoin has declined with the introduction of safer alternatives.
随着更安全替代品的引入，美芬妥英的临床使用已经减少。
hydroxylation of mephenytoin is significantly slower in poor metabolizers.
在弱代谢者中，美芬妥英的羟基化速度明显较慢。
physicians monitor blood levels to prevent mephenytoin toxicity during long-term therapy.
医生监测血液水平以防止长期治疗期间出现美芬妥英毒性。
chronic administration of mephenytoin may induce hepatic microsomal enzymes.
长期服用美芬妥英可能会诱导肝微粒体酶。
this study investigates the pharmacokinetics of mephenytoin in human subjects.
本研究调查美芬妥英在人体受试者中的药代动力学。
severe gingival hyperplasia is a potential side effect of taking mephenytoin.
严重的牙龈增生是服用美芬妥英的潜在副作用。
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